Transmitted by air in 1350bc smallpox hit Egypt, prisoners spread smallpox and killed their king, and transported by merchants, in the 20th century alone killed more than 1 billion people. 1022 ad in the book "the correct treatment of smallpox" in the book the monk that lived in O Mei Shan ground up smallpox scabs to let healthy people inhale it, and if they survived smallpox they never got smallpox again.
Named Variolation.
Then Edward Jenner found in dairy maids, dairy maids got cowpox, which infects cows, women who got cowpox did not get smallpox.
Smallpox and cowpox are from the same family of viruses, so cowpox was used to make a cure for smallpox.
Vaccination was allowed but Variolation was not.
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